The Nerbonne laboratory studies the molecular, cellular and systemic mechanisms involved in the physiological regulation of cardiac and neuronal membrane excitability, how these mechanisms go awry in inherited and acquired disease, and the impact of derangements in membrane excitability on cardiovascular and nervous system functioning.
Nerbonne Lab 2018: Front (L to R): Miguel Campos, Joey Ransdell, Jeanne Nerbonne, Tracey Hermanstyne, Rebecca Mellor. Back (L to R): Denye Mickens, Rick Wilson, and David Wang
- Eric K. Johnson, Steven J. Springer, Wei Wang, Edward J. Dranoff, Yan Zhang, Evelyn M. Kanter, Kathryn A. Yamada, and Jeanne M. Nerbonne. Differential expression and remodeling of transient outward potassium currents in human Left ventricles. Circulation: Arrhythmia and Electrophysiology. 2018 Sept 17; 11:e005914
- Tracey O. Hermanstyne, Daniel Granados-Fuentes, Rebecca L. Mellor, Erik D. Herzog and Jeanne M. Nerbonne. Acute knockdown of Kv4.1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior. eNeuro. 2017 May 12; 4 (3) ENEURO.0377-16.2017
- Joseph L. Ransdell, Edward Dranoff, Brandon Lau, Wan-Lin Lo, David L. Donermeyer, Paul M. Allen, and Jeanne M. Nerbonne. Loss of Navβ4-mediated regulation of sodium currents in adult Purkinje neurons disrupts firing and impairs motor coordination and balance. Cell Reports. 2017 Apr 18; 19(3): 532–544.